Two sample MR report
HLA-DQB1_Endothelial Cell (Endo) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0124659 | 0.5760408 | 0.9837711 |
| Weighted median | 6 | -0.1022033 | 0.0313545 | 0.0011157 |
| Inverse variance weighted | 6 | -0.1004625 | 0.0260410 | 0.0001144 |
| Simple mode | 6 | -0.1024633 | 0.0408695 | 0.0540202 |
| Weighted mode | 6 | -0.1022694 | 0.0424355 | 0.0608645 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1164297 | 4 | 0.9983699 |
| Inverse variance weighted | 0.1549410 | 5 | 0.9995243 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0600409 | 0.305952 | 0.8539868 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001655 | 0 | TRUE | 0.2244708 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
